TITLE: CYTOKINE FRONTIERS: REGULATION OF IMMUNE RESPONSES IN
HEALTH AND DISEASE
PUBLISHER: SPRINGER LANGUAGE: ENGLISH
LINK:
http://is.gd/LBPXRy RELEASE TYPE: RETAIL
FORMAT: PDF RELEASE DATE: 2015.01.28
ISBN: 9784431544425 STORE DATE: 2014
SAVED.MONEY: 125 EURO DISKCOUNT: 02 x 05MB
AUTHOR: YOSHIMOTO, TAKAYUKI, YOSHIMOTO, TOMOHIRO
(EDS.)
BOOK
This book guides the reader through the latest research on the
cytokine network, covering signaling pathways, control of the
immune response, and potential therapeutics. Different cytokines
stimulate diverse responses in various phases of inflammation and
immunity, including the innate immune response, the generation of
effector T cells, and the development of antibodies by the
humoral immune system. It is now clear that the pathophysiology
of many infectious, autoimmune, allergic, and malignant diseases
can be largely explained by which cytokines are induced and
subsequently regulate the cellular responses. In clinical
medicine, cytokines are involved in a wide spectrum of diseases
This book describes in three parts the properties and roles of 15
key cytokines under physiological and pathological conditions
Part I presents nine cytokines associated with inflammatory
disorders, pro-inflammatory cytokines, and the recently
identified new helper T (Th) subset: Th17 cells. Part II gives
details of three cytokines associated with allergic disorders
including Th2 responses and recently identified types of innate
cells. Part III describes three cytokines that are associated
with immunological tolerance and anti-inflammation, including
regulatory T (Treg) cells, IL-10-producing Treg (Tr1) cells, and
inducible IL-35-producing Treg (iTr35) cells. Cytokines are
considered to be important as therapeutic targets for specific
agonists or antagonists in numerous immune and inflammatory
diseases. The ultimate goal of this book is to facilitate the
development of therapeutic treatments for such diseases which has
been limited by an insufficient understanding of the biology of
cytokines and the complicated network that they create
